Adenovirus Transcriptome in Human Cells Infected with  ChAdOx1-Vectored Candidate HIV-1 Vaccine Is Dominated by High Levels of Correctly Spliced HIVconsv1&62 Transgene RNA

We develop candidate HIV-1 vaccines, of which two components, ChAdOx1.tHIVconsv1 (C1) and ChAdOx1.HIVconsv62 (C62), are delivered by the simian adenovirus-derived vaccine vector ChAdOx1. Aberrant adenovirus RNA splicing involving transgene(s) coding for the SARS-CoV-2 spike was suggested as an aetio...

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Detalles Bibliográficos
Autores principales: Matthews, David A., Milligan, Rachel, Wee, Edmund G., Hanke, Tomáš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384973/
https://www.ncbi.nlm.nih.gov/pubmed/37515003
http://dx.doi.org/10.3390/vaccines11071187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384973/
https://www.ncbi.nlm.nih.gov/pubmed/37515003
http://dx.doi.org/10.3390/vaccines11071187

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