Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents

A small set of indole-based derivatives, IV and Va–I, was designed and synthesized. Compounds Va–i demonstrated promising antiproliferative activity, with GI(50) values ranging from 26 nM to 86 nM compared to erlotinib’s 33 nM. The most potent antiproliferative derivatives—Va, Ve, Vf, Vg, and Vh—wer...

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Detalles Bibliográficos
Autores principales: Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdelrahman, Mostafa H., Trembleau, Laurent, Youssif, Bahaa G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385579/
https://www.ncbi.nlm.nih.gov/pubmed/37513950
http://dx.doi.org/10.3390/ph16071039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385579/
https://www.ncbi.nlm.nih.gov/pubmed/37513950
http://dx.doi.org/10.3390/ph16071039

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