Cargando…

Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents

A small set of indole-based derivatives, IV and Va–I, was designed and synthesized. Compounds Va–i demonstrated promising antiproliferative activity, with GI(50) values ranging from 26 nM to 86 nM compared to erlotinib’s 33 nM. The most potent antiproliferative derivatives—Va, Ve, Vf, Vg, and Vh—wer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdelrahman, Mostafa H., Trembleau, Laurent, Youssif, Bahaa G. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385579/ https://www.ncbi.nlm.nih.gov/pubmed/37513950 http://dx.doi.org/10.3390/ph16071039

Ejemplares similares

Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2022)

Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFR(T790M)/BRAF(V600E) Pathways
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR(WT/)EGFR(T790M) inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2022)

Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAF(V600E) Inhibitory Pathways
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

One-Pot Synthesis of 1-Thia-4-azaspiro[4.4/5]alkan-3-ones via Schiff Base: Design, Synthesis, and Apoptotic Antiproliferative Properties of Dual EGFR/BRAF(V600E) Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAF(V600E) Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF(V600E) Dual Inhibitors Endowed with Antiproliferative Activity
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAF(V600E): Design, Synthesis, and Antiproliferative Activity
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2023)

Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Tri-Aryl Imidazole-Benzene Sulfonamide Hybrids as Promising Selective Carbonic Anhydrase IX and XII Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2021)

Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2021)

Structure-based design, synthesis, and biological evaluation of novel piperine–resveratrol hybrids as antiproliferative agents targeting SIRT-2
por: Tantawy, Ahmed H., et al.
Publicado: (2021)

Design and synthesis of new thiazolidinone/uracil derivatives as antiproliferative agents targeting EGFR and/or BRAF(V600E)
por: Alshammari, Mohammed B., et al.
Publicado: (2022)

Design, Synthesis, and Antibacterial Screening of Some Novel Heteroaryl-Based Ciprofloxacin Derivatives as DNA Gyrase and Topoisomerase IV Inhibitors
por: Al-Wahaibi, Lamya H., et al.
Publicado: (2021)

Design and synthesis of thiadiazolo-carboxamide bridged β-carboline-indole hybrids: DNA intercalative topo-IIα inhibition with promising antiproliferative activity
por: Tokala, Ramya, et al.
Publicado: (2020)

Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1H)-ones as Multi-Target Inhibitors
por: El-Sheref, Essmat M., et al.
Publicado: (2023)

Synthesis of novel amidines via one-pot three component reactions: Selective topoisomerase I inhibitors with antiproliferative properties
por: El-Sheref, Essmat M., et al.
Publicado: (2022)

Design and Synthesis of (2-oxo-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents
por: El-Sheref, Essmat M., et al.
Publicado: (2021)

Synthesis and Antiproliferative Activity of Novel Heterocyclic Indole-Trimethoxyphenyl Conjugates
por: Cahill, Michael M., et al.
Publicado: (2017)

Antiproliferative Effect of Indole Phytoalexins
por: Chripkova, Martina, et al.
Publicado: (2016)

Marine-Inspired Bis-indoles Possessing Antiproliferative Activity against Breast Cancer; Design, Synthesis, and Biological Evaluation
por: Eldehna, Wagdy M., et al.
Publicado: (2020)

Synthesis and Biological Evaluation of Apigenin Derivatives as Antibacterial and Antiproliferative Agents
por: Liu, Rui, et al.
Publicado: (2013)

Synthesis and Biological Evaluation of Amino Chalcone Derivatives as Antiproliferative Agents
por: Lu, Chao-Fan, et al.
Publicado: (2020)

Green Synthesis of Oxoquinoline-1(2H)-Carboxamide as Antiproliferative and Antioxidant Agents: An Experimental and In-Silico Approach to High Altitude Related Disorders
por: Ali, Amena, et al.
Publicado: (2022)

Synthesis and Antiproliferative Activity against Cancer Cells of Indole-Aryl-Amide Derivatives
por: Zhao, Junwei, et al.
Publicado: (2022)

Design, Synthesis, and Evaluation of Novel Indole Hybrid Chalcones and Their Antiproliferative and Antioxidant Activity
por: Kudličková, Zuzana, et al.
Publicado: (2023)

New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity
por: Maghraby, Mohamed T-E, et al.
Publicado: (2023)

Design, Synthesis, and Biological Evaluation of Artemisinin-Indoloquinoline Hybrids as Potent Antiproliferative Agents
por: Wang, Li, et al.
Publicado: (2014)

Novel Coumarin 7-Carboxamide/Sulfonamide Derivatives as Potential Fungicidal Agents: Design, Synthesis, and Biological Evaluation
por: Zhang, Shu-Guang, et al.
Publicado: (2022)

Synthesis and In Vitro Antiproliferative Activity of New 1-Phenyl-3-(4-(pyridin-3-yl)phenyl)urea Scaffold-Based Compounds
por: Al-Sanea, Mohammad M., et al.
Publicado: (2018)

Substituted N-Benzylpyrazine-2-carboxamides: Synthesis and Biological Evaluation (†)
por: Servusová, Barbora, et al.
Publicado: (2012)

Synthesis and Biological Activity Evaluation of Coumarin-3-Carboxamide Derivatives
por: Phutdhawong, Weerachai, et al.
Publicado: (2021)

Synthesis and Evaluation of Pyrimidine Steroids as Antiproliferative Agents
por: Cortés-Percino, Alejandra, et al.
Publicado: (2019)

Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents
por: Tahlan, Sumit, et al.
Publicado: (2019)

Molecular docking, synthesis and biological significance of pyrimidine analogues as prospective antimicrobial and antiproliferative agents
por: Kumar, Sanjiv, et al.
Publicado: (2019)

New Natural Eugenol Derivatives as Antiproliferative Agents: Synthesis, Biological Evaluation, and Computational Studies
por: Nazreen, Syed, et al.
Publicado: (2023)

New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity
por: Al-Wabli, Reem I, et al.
Publicado: (2020)

Design, Synthesis and Antiproliferative Evaluation of Bis-Indole Derivatives with a Phenyl Linker: Focus on Autophagy
por: Marianna, Budovska, et al.
Publicado: (2022)

Design, synthesis and evaluation of novel indole-2-carboxamides for growth inhibition of Mycobacterium tuberculosis and paediatric brain tumour cells
por: Alsayed, Shahinda S. R., et al.
Publicado: (2021)

Weak interactions in the crystal structures of two indole derivatives
por: Kerr, Jamie R., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_6mfl0ondos0t1p5nfnl320stvl