In Silico Screening of Inhibitors of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease

The Venezuelan equine encephalitis virus (VEEV) nonstructural protein 2 (nsP2) cysteine protease (EC 3.4.22.B79) is essential for viral replication. High throughput in silico/in vitro screening using a focused set of known cysteine protease inhibitors identified two epoxysuccinyl prodrugs, E64d and...

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Detalles Bibliográficos
Autores principales: Hu, Xin, Morazzani, Elaine, Compton, Jaimee R., Harmon, Moeshia, Soloveva, Veronica, Glass, Pamela J., Garcia, Andres Dulcey, Marugan, Juan J., Legler, Patricia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385868/
https://www.ncbi.nlm.nih.gov/pubmed/37515189
http://dx.doi.org/10.3390/v15071503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385868/
https://www.ncbi.nlm.nih.gov/pubmed/37515189
http://dx.doi.org/10.3390/v15071503

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