Physiologically Based Pharmacokinetic Modelling to Predict Imatinib Exposures in Cancer Patients with Renal Dysfunction: A Case Study

Imatinib is mainly metabolised by CYP3A4 and CYP2C8 and is extensively bound to α-acid glycoprotein (AAG). A physiologically based pharmacokinetic (PBPK) model for imatinib describing the CYP3A4-mediated autoinhibition during multiple dosing in gastrointestinal stromal tumor patients with normal ren...

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Detalles Bibliográficos
Autores principales: Rowland Yeo, Karen, Hatley, Oliver, Small, Ben G., Johnson, Trevor N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386083/
https://www.ncbi.nlm.nih.gov/pubmed/37514108
http://dx.doi.org/10.3390/pharmaceutics15071922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386083/
https://www.ncbi.nlm.nih.gov/pubmed/37514108
http://dx.doi.org/10.3390/pharmaceutics15071922

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