Design and Synthesis of AMPK Activators and GDF15 Inducers

Targeting growth differentiation factor 15 (GDF15) is a recent strategy for the treatment of obesity and type 2 diabetes mellitus (T2DM). Here, we designed, synthesized, and pharmacologically evaluated in vitro a novel series of AMPK activators to upregulate GDF15 levels. These compounds were struct...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Meijian, Bagán, Andrea, Martínez, Donna, Barroso, Emma, Palomer, Xavier, Vázquez, Santiago, Escolano, Carmen, Vázquez-Carrera, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386161/
https://www.ncbi.nlm.nih.gov/pubmed/37513338
http://dx.doi.org/10.3390/molecules28145468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386161/
https://www.ncbi.nlm.nih.gov/pubmed/37513338
http://dx.doi.org/10.3390/molecules28145468

Ejemplares similares