Development of Atomoxetine-Loaded NLC In Situ Gel for Nose-to-Brain Delivery: Optimization, In Vitro, and Preclinical Evaluation

The present study investigates the brain-targeted efficiency of atomoxetine (AXT)-loaded nanostructured lipid carrier (NLC)-laden thermosensitive in situ gel after intranasal administration. AXT-NLC was prepared by the melt emulsification ultrasonication method and optimized using the Box–Behnken de...

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Detalles Bibliográficos
Autores principales: Mohanty, Dibyalochan, Alsaidan, Omar Awad, Zafar, Ameeduzzafar, Dodle, Trishala, Gupta, Jeetendra Kumar, Yasir, Mohd, Mohanty, Anshuman, Khalid, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386213/
https://www.ncbi.nlm.nih.gov/pubmed/37514171
http://dx.doi.org/10.3390/pharmaceutics15071985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386213/
https://www.ncbi.nlm.nih.gov/pubmed/37514171
http://dx.doi.org/10.3390/pharmaceutics15071985

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