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Hydrolytic Mechanism of a Metalloenzyme Is Modified by the Nature of the Coordinated Metal Ion
The nuclease domain of colicin E7 cleaves double-strand DNA non-specifically. Zn(2+) ion was shown to be coordinated by the purified NColE7 as its native metal ion. Here, we study the structural and catalytic aspects of the interaction with Ni(2+), Cu(2+) and Cd(2+) non-endogenous metal ions and the...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386286/ https://www.ncbi.nlm.nih.gov/pubmed/37513383 http://dx.doi.org/10.3390/molecules28145511 |