A MOR Antagonist with High Potency and Antagonist Efficacy among Diastereomeric C9-Alkyl-Substituted N-Phenethyl-5-(3-hydroxy)phenylmorphans

The 5-(3-hydroxy)phenylmorphan structural class of compounds are unlike the classical morphinans, 4,5-epoxymorphinans, and 6,7-benzomorphans, in that they have an equatorially oriented aromatic ring rather than the axial orientation of that ring found in the classical opioids. This modified and simp...

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Detalles Bibliográficos
Autores principales: Chambers, Dana R., Sulima, Agnieszka, Luo, Dan, Prisinzano, Thomas E., Jacobson, Arthur E., Rice, Kenner C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386414/
https://www.ncbi.nlm.nih.gov/pubmed/37513283
http://dx.doi.org/10.3390/molecules28145411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386414/
https://www.ncbi.nlm.nih.gov/pubmed/37513283
http://dx.doi.org/10.3390/molecules28145411

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