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A MOR Antagonist with High Potency and Antagonist Efficacy among Diastereomeric C9-Alkyl-Substituted N-Phenethyl-5-(3-hydroxy)phenylmorphans
The 5-(3-hydroxy)phenylmorphan structural class of compounds are unlike the classical morphinans, 4,5-epoxymorphinans, and 6,7-benzomorphans, in that they have an equatorially oriented aromatic ring rather than the axial orientation of that ring found in the classical opioids. This modified and simp...
Autores principales: | Chambers, Dana R., Sulima, Agnieszka, Luo, Dan, Prisinzano, Thomas E., Jacobson, Arthur E., Rice, Kenner C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386414/ https://www.ncbi.nlm.nih.gov/pubmed/37513283 http://dx.doi.org/10.3390/molecules28145411 |
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