An Intriguing Purview on the Design of Macrocyclic Inhibitors for Unexplored Protein Kinases through Their Binding Site Comparison

Kinases play an important role in regulating various intracellular signaling pathways that control cell proliferation, differentiation, survival, and other cellular processes, and their deregulation causes more than 400 diseases. Consequently, macrocyclization can be considered a noteworthy approach...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhujbal, Swapnil P., Hah, Jung-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386424/
https://www.ncbi.nlm.nih.gov/pubmed/37513921
http://dx.doi.org/10.3390/ph16071009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386424/
https://www.ncbi.nlm.nih.gov/pubmed/37513921
http://dx.doi.org/10.3390/ph16071009

Ejemplares similares