Novel covalent CDK7 inhibitor potently induces apoptosis in acute myeloid leukemia and synergizes with Venetoclax

INTRODUCTION: The emergence of resistance to the highly successful BCL2-directed therapy is a major unmet need in acute myeloid leukemia (AML), an aggressive malignancy with poor survival rates. Towards identifying therapeutic options for AML patients who progress on BCL2-directed therapy, we studie...

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Detalles Bibliográficos
Autores principales: Gaur, Tarang, Poddutoori, Ramulu, Khare, Leena, Bagal, Bhausaheb, Rashmi, Sonal, Patkar, Nikhil, Tembhare, Prashant, PG, Subramanian, Shetty, Dhanlaxmi, Dutt, Amit, Zhang, Qi, Konopleva, Marina, Platzbeckar, Uwe, Gupta, Sudeep, Samajdar, Susanta, Ramchandra, Murali, Khattry, Navin, Hasan, Syed K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386772/
https://www.ncbi.nlm.nih.gov/pubmed/37507802
http://dx.doi.org/10.1186/s13046-023-02750-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386772/
https://www.ncbi.nlm.nih.gov/pubmed/37507802
http://dx.doi.org/10.1186/s13046-023-02750-w

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