A Joint Pharmacokinetic Model for the Simultaneous Description of Plasma and Whole Blood Tacrolimus Concentrations in Kidney and Lung Transplant Recipients

BACKGROUND AND OBJECTIVE: Historically, dosing of tacrolimus is guided by therapeutic drug monitoring (TDM) of the whole blood concentration, which is strongly influenced by haematocrit. The therapeutic and adverse effects are however expected to be driven by the unbound exposure, which could be bet...

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Detalles Bibliográficos
Autores principales: Koomen, Jeroen V., Knobbe, Tim J., Zijp, Tanja R., Kremer, Daan, Gan, C. Tji, Verschuuren, Erik A. M., Bakker, Stephan J. L., Touw, Daan J., Colin, Pieter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386913/
https://www.ncbi.nlm.nih.gov/pubmed/37306899
http://dx.doi.org/10.1007/s40262-023-01259-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386913/
https://www.ncbi.nlm.nih.gov/pubmed/37306899
http://dx.doi.org/10.1007/s40262-023-01259-x

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