Semi-physiological Enriched Population Pharmacokinetic Modelling to Predict the Effects of Pregnancy on the Pharmacokinetics of Cytotoxic Drugs

BACKGROUND AND OBJECTIVE: As a result of changes in physiology during pregnancy, the pharmacokinetics (PK) of drugs can be altered. It is unclear whether under- or overexposure occurs in pregnant cancer patients and thus also whether adjustments in dosing regimens are required. Given the severity of...

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Detalles Bibliográficos
Autores principales: Janssen, J. M., Damoiseaux, D., van Hasselt, J. G. C., Amant, F. C. H., van Calsteren, K., Beijnen, J. H., Huitema, A. D. R., Dorlo, T. P. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386937/
https://www.ncbi.nlm.nih.gov/pubmed/37351792
http://dx.doi.org/10.1007/s40262-023-01263-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386937/
https://www.ncbi.nlm.nih.gov/pubmed/37351792
http://dx.doi.org/10.1007/s40262-023-01263-1

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