Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations

The class Frizzled of G protein-coupled receptors (GPCRs), consisting of ten Frizzled (FZD(1-10)) paralogs and Smoothened, remains one of the most enigmatic GPCR families. This class mediates signaling predominantly through Disheveled (DVL) or heterotrimeric G proteins. However, the mechanisms under...

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Detalles Bibliográficos
Autores principales: Grätz, Lukas, Kowalski-Jahn, Maria, Scharf, Magdalena M., Kozielewicz, Pawel, Jahn, Michael, Bous, Julien, Lambert, Nevin A., Gloriam, David E., Schulte, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387068/
https://www.ncbi.nlm.nih.gov/pubmed/37516754
http://dx.doi.org/10.1038/s41467-023-40213-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387068/
https://www.ncbi.nlm.nih.gov/pubmed/37516754
http://dx.doi.org/10.1038/s41467-023-40213-0

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