Cargando…
Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations
The class Frizzled of G protein-coupled receptors (GPCRs), consisting of ten Frizzled (FZD(1-10)) paralogs and Smoothened, remains one of the most enigmatic GPCR families. This class mediates signaling predominantly through Disheveled (DVL) or heterotrimeric G proteins. However, the mechanisms under...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387068/ https://www.ncbi.nlm.nih.gov/pubmed/37516754 http://dx.doi.org/10.1038/s41467-023-40213-0 |