An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis

Cholesterol is an essential membrane structural component and steroid hormone precursor, and is involved in numerous signaling processes. Astrocytes regulate brain cholesterol homeostasis and they supply cholesterol to the needs of neurons. ATP-binding cassette transporter A1 (ABCA1) is the main cho...

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Detalles Bibliográficos
Autores principales: Talvio, Karo, Wagner, Victoria A., Minkeviciene, Rimante, Kirkwood, Jay S., Kulinich, Anna O., Umemori, Juzoh, Bhatia, Anil, Hur, Manhoi, Käkelä, Reijo, Ethell, Iryna M., Castrén, Maija L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387075/
https://www.ncbi.nlm.nih.gov/pubmed/37516746
http://dx.doi.org/10.1038/s42003-023-05147-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387075/
https://www.ncbi.nlm.nih.gov/pubmed/37516746
http://dx.doi.org/10.1038/s42003-023-05147-9

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