Optical and pharmacological manipulation of hypoglossal motor nucleus identifies differential effects of taltirelin on sleeping tonic motor activity and responsiveness

Pharyngeal muscle activity and responsiveness are key pathophysiological traits in human obstructive sleep apnea (OSA) and strong contributors to improvements with pharmacotherapy. The thyrotropin-releasing hormone (TRH) analog taltirelin is of high pre-clinical interest given its neuronal-stimulant...

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Detalles Bibliográficos
Autores principales: Aggarwal, Jasmin, Ladha, Raina, Liu, Wen-Ying, Liu, Hattie, Horner, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387086/
https://www.ncbi.nlm.nih.gov/pubmed/37516800
http://dx.doi.org/10.1038/s41598-023-39562-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387086/
https://www.ncbi.nlm.nih.gov/pubmed/37516800
http://dx.doi.org/10.1038/s41598-023-39562-z

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