Co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells attenuates human NK cell-mediated degranulation

Natural killer (NK) cells play an important role in immune rejection in solid organ transplantation. To mitigate human NK cell activation in xenotransplantation, introducing inhibitory ligands on xenografts via genetic engineering of pigs may protect the graft from human NK cell-mediated cytotoxicit...

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Detalles Bibliográficos
Autores principales: Cross-Najafi, Arthur A., Farag, Kristine, Isidan, Abdulkadir, Li, Wei, Zhang, Wenjun, Lin, Zhansong, Walsh, Julia R., Lopez, Kevin, Park, Yujin, Higgins, Nancy G., Cooper, David K.C., Ekser, Burcin, Li, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387534/
https://www.ncbi.nlm.nih.gov/pubmed/37529053
http://dx.doi.org/10.3389/fimmu.2023.1217809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387534/
https://www.ncbi.nlm.nih.gov/pubmed/37529053
http://dx.doi.org/10.3389/fimmu.2023.1217809

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