Anti-topoisomerase, but not anti-centromere B cell responses in systemic sclerosis display active, Ig-secreting cells associated with lung fibrosis

OBJECTIVES: Almost all patients with systemic sclerosis (SSc) harbour autoantibodies. Anti-topoisomerase antibodies (ATA) and anti-centromere antibodies (ACA) are most prevalent and associate with distinct clinical phenotypes. B cell responses underlying these phenotypes are ill-defined. To understa...

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Detalles Bibliográficos
Autores principales: Wortel, Corrie M, Liem, Sophie IE, van Leeuwen, Nina M, Boonstra, Maaike, Fehres, Cynthia M, Stöger, Lauran, Huizinga, Tom WJ, Toes, René EM, De Vries-Bouwstra, Jeska, Scherer, Hans U
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Systemic Sclerosis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387632/
https://www.ncbi.nlm.nih.gov/pubmed/37507206
http://dx.doi.org/10.1136/rmdopen-2023-003148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387632/
https://www.ncbi.nlm.nih.gov/pubmed/37507206
http://dx.doi.org/10.1136/rmdopen-2023-003148

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