Knockdown of 11β-hydroxysteroid dehydrogenase type 1 alleviates LPS-induced myocardial dysfunction through the AMPK/SIRT1/PGC-1α pathway

Sepsis-induced myocardial dysfunction is primarily accompanied by severe sepsis, which is associated with high morbidity and mortality. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), encoded by Hsd11b1, is a reductase that can convert inactive cortisone into metabolically active cortisol, but t...

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Detalles Bibliográficos
Autores principales: Zhu, Dongmei, Luo, Lingli, Zeng, Hanjie, Zhang, Zheng, Huang, Min, Zhou, Suming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387747/
https://www.ncbi.nlm.nih.gov/pubmed/37246430
http://dx.doi.org/10.7555/JBR.36.20220212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387747/
https://www.ncbi.nlm.nih.gov/pubmed/37246430
http://dx.doi.org/10.7555/JBR.36.20220212

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