Optimizing and developing a scalable, chemically defined, animal component-free lentiviral vector production process in a fixed-bed bioreactor

Lentiviral vectors (LVVs) play a critical role in gene delivery for ex vivo gene-modified cell therapies. However, the lack of scalable LVV production methods and the high cost associated with them may limit their use. In this work, we demonstrate the optimization and development of a scalable, chem...

Descripción completa

Detalles Bibliográficos
Autores principales: Fiol, Carme Ripoll, Collignon, Marie-Laure, Welsh, John, Rafiq, Qasim A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388200/
https://www.ncbi.nlm.nih.gov/pubmed/37528866
http://dx.doi.org/10.1016/j.omtm.2023.06.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388200/
https://www.ncbi.nlm.nih.gov/pubmed/37528866
http://dx.doi.org/10.1016/j.omtm.2023.06.011

Ejemplares similares