The E3 ligase TRIM31 regulates hematopoietic stem cell homeostasis and MLL-AF9 leukemia

Hematopoietic stem cells (HSC) are kept in a quiescent state to maintain their self-renewal capacity. Proper regulation of cyclin-dependent kinases (CDK) and cyclin proteins is critical for the maintenance of HSC homeostasis. Here, we found that the E3 ligase, TRIM31, regulates HSC homeostasis and l...

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Detalles Bibliográficos
Autores principales: Zhang, Kai, Liu, Dingdong, Li, Yafei, Shi, Zhencan, Guo, Jun, Gao, Chengjiang, Wang, Hu, Ju, Zhenyu, Diao, Daojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2023
Materias:
Article - Hematopoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388288/
https://www.ncbi.nlm.nih.gov/pubmed/36632737
http://dx.doi.org/10.3324/haematol.2022.281955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388288/
https://www.ncbi.nlm.nih.gov/pubmed/36632737
http://dx.doi.org/10.3324/haematol.2022.281955

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