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The E3 ligase TRIM31 regulates hematopoietic stem cell homeostasis and MLL-AF9 leukemia

Hematopoietic stem cells (HSC) are kept in a quiescent state to maintain their self-renewal capacity. Proper regulation of cyclin-dependent kinases (CDK) and cyclin proteins is critical for the maintenance of HSC homeostasis. Here, we found that the E3 ligase, TRIM31, regulates HSC homeostasis and l...

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Detalles Bibliográficos
Autores principales:	Zhang, Kai, Liu, Dingdong, Li, Yafei, Shi, Zhencan, Guo, Jun, Gao, Chengjiang, Wang, Hu, Ju, Zhenyu, Diao, Daojun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2023
Materias:	Article - Hematopoiesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388288/ https://www.ncbi.nlm.nih.gov/pubmed/36632737 http://dx.doi.org/10.3324/haematol.2022.281955

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