Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes

[Image: see text] Within druggable target space, new small-molecule modalities, particularly covalent inhibitors and targeted degraders, have expanded the repertoire of medicinal chemists. Molecules with such modes of action have a large potential not only as drugs but also as chemical probes. Crite...

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Detalles Bibliográficos
Autores principales: Hartung, Ingo V., Rudolph, Joachim, Mader, Mary M., Mulder, Monique P. C., Workman, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388296/
https://www.ncbi.nlm.nih.gov/pubmed/37403870
http://dx.doi.org/10.1021/acs.jmedchem.3c00550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388296/
https://www.ncbi.nlm.nih.gov/pubmed/37403870
http://dx.doi.org/10.1021/acs.jmedchem.3c00550

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