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Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes
[Image: see text] Within druggable target space, new small-molecule modalities, particularly covalent inhibitors and targeted degraders, have expanded the repertoire of medicinal chemists. Molecules with such modes of action have a large potential not only as drugs but also as chemical probes. Crite...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388296/ https://www.ncbi.nlm.nih.gov/pubmed/37403870 http://dx.doi.org/10.1021/acs.jmedchem.3c00550 |