Mixture-Based Screening of Focused Combinatorial Libraries by NMR: Application to the Antiapoptotic Protein hMcl-1

[Image: see text] We report on an innovative ligand discovery strategy based on protein NMR-based screening of a combinatorial library of ∼125,000 compounds that was arranged in 96 distinct mixtures. Using sensitive solution protein NMR spectroscopy and chemical perturbation-based screening followed...

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Detalles Bibliográficos
Autores principales: Alboreggia, Giulia, Udompholkul, Parima, Baggio, Carlo, Pellecchia, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388297/
https://www.ncbi.nlm.nih.gov/pubmed/37464766
http://dx.doi.org/10.1021/acs.jmedchem.3c01073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388297/
https://www.ncbi.nlm.nih.gov/pubmed/37464766
http://dx.doi.org/10.1021/acs.jmedchem.3c01073

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