Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors

[Image: see text] In search of a potent small molecular PD-L1 inhibitor, we designed and synthesized a compound based on a 2-hydroxy-4-phenylthiophene-3-carbonitrile moiety. Ligand’s performance was tested in vitro and compared side-by-side with a known PD-L1 antagonist with a proven bioactivity BMS...

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Detalles Bibliográficos
Autores principales: Ważyńska, Marta A., Butera, Roberto, Requesens, Marta, Plat, Annechien, Zarganes-Tzitzikas, Tryfon, Neochoritis, Constantinos G., Plewka, Jacek, Skalniak, Lukasz, Kocik-Krol, Justyna, Musielak, Bogdan, Magiera-Mularz, Katarzyna, Rodriguez, Ismael, Blok, Simon N., de Bruyn, Marco, Nijman, Hans W., Elsinga, Philip H., Holak, Tad A., Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388299/
https://www.ncbi.nlm.nih.gov/pubmed/37450644
http://dx.doi.org/10.1021/acs.jmedchem.3c00254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388299/
https://www.ncbi.nlm.nih.gov/pubmed/37450644
http://dx.doi.org/10.1021/acs.jmedchem.3c00254

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