Fluorescent Ligands Enable Target Engagement Studies for the Intracellular Allosteric Binding Site of the Chemokine Receptor CXCR2

[Image: see text] Herein, we report the structure-based development of fluorescent ligands targeting the intracellular allosteric binding site (IABS) of CXC chemokine receptor 2 (CXCR2), a G protein-coupled receptor (GPCR) that has been pursued as a drug target in oncology and inflammation. Starting...

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Detalles Bibliográficos
Autores principales: Huber, Max E., Wurnig, Silas, Toy, Lara, Weiler, Corinna, Merten, Nicole, Kostenis, Evi, Hansen, Finn K., Schiedel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388362/
https://www.ncbi.nlm.nih.gov/pubmed/37463496
http://dx.doi.org/10.1021/acs.jmedchem.3c00769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388362/
https://www.ncbi.nlm.nih.gov/pubmed/37463496
http://dx.doi.org/10.1021/acs.jmedchem.3c00769

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