Targeting NEDD8-activating enzyme for cancer therapy: developments, clinical trials, challenges and future research directions

NEDDylation, a post-translational modification through three-step enzymatic cascades, plays crucial roles in the regulation of diverse biological processes. NEDD8-activating enzyme (NAE) as the only activation enzyme in the NEDDylation modification has become an attractive target to develop anticanc...

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Detalles Bibliográficos
Autores principales: Fu, Dong-Jun, Wang, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388525/
https://www.ncbi.nlm.nih.gov/pubmed/37525282
http://dx.doi.org/10.1186/s13045-023-01485-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388525/
https://www.ncbi.nlm.nih.gov/pubmed/37525282
http://dx.doi.org/10.1186/s13045-023-01485-7

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