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Targeting NEDD8-activating enzyme for cancer therapy: developments, clinical trials, challenges and future research directions
NEDDylation, a post-translational modification through three-step enzymatic cascades, plays crucial roles in the regulation of diverse biological processes. NEDD8-activating enzyme (NAE) as the only activation enzyme in the NEDDylation modification has become an attractive target to develop anticanc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388525/ https://www.ncbi.nlm.nih.gov/pubmed/37525282 http://dx.doi.org/10.1186/s13045-023-01485-7 |