CAR NK-92 cell–mediated depletion of residual TCR(+) cells for ultrapure allogeneic TCR-deleted CAR T-cell products

Graft-versus-host disease (GVHD) is a major risk of the administration of allogeneic chimeric antigen receptor (CAR)-redirected T cells to patients who are HLA unmatched. Gene editing can be used to disrupt potentially alloreactive T-cell receptors (TCRs) in CAR T cells and reduce the risk of GVHD....

Descripción completa

Detalles Bibliográficos
Autores principales: Kath, Jonas, Du, Weijie, Martini, Stefania, Elsallab, Magdi, Franke, Clemens, Hartmann, Laura, Drosdek, Vanessa, Glaser, Viktor, Stein, Maik, Schmueck-Henneresse, Michael, Reinke, Petra, Volk, Hans-Dieter, Abou-el-Enein, Mohamed, Wagner, Dimitrios L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Gene Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388728/
https://www.ncbi.nlm.nih.gov/pubmed/37196643
http://dx.doi.org/10.1182/bloodadvances.2022009397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388728/
https://www.ncbi.nlm.nih.gov/pubmed/37196643
http://dx.doi.org/10.1182/bloodadvances.2022009397

Ejemplares similares