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CAR NK-92 cell–mediated depletion of residual TCR(+) cells for ultrapure allogeneic TCR-deleted CAR T-cell products

Graft-versus-host disease (GVHD) is a major risk of the administration of allogeneic chimeric antigen receptor (CAR)-redirected T cells to patients who are HLA unmatched. Gene editing can be used to disrupt potentially alloreactive T-cell receptors (TCRs) in CAR T cells and reduce the risk of GVHD....

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Detalles Bibliográficos
Autores principales:	Kath, Jonas, Du, Weijie, Martini, Stefania, Elsallab, Magdi, Franke, Clemens, Hartmann, Laura, Drosdek, Vanessa, Glaser, Viktor, Stein, Maik, Schmueck-Henneresse, Michael, Reinke, Petra, Volk, Hans-Dieter, Abou-el-Enein, Mohamed, Wagner, Dimitrios L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2023
Materias:	Gene Therapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388728/ https://www.ncbi.nlm.nih.gov/pubmed/37196643 http://dx.doi.org/10.1182/bloodadvances.2022009397

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