Treatment of thrombocytopenia and thrombosis in HIT in mice using deglycosylated KKO: a novel therapeutic?

Heparin-induced thrombocytopenia (HIT) is characterized by thrombocytopenia associated with a highly prothrombotic state due to the development of pathogenic antibodies that recognize human platelet factor 4 (hPF4) complexed with various polyanions. Although nonheparin anticoagulants are the mainsta...

Descripción completa

Detalles Bibliográficos
Autores principales: Sarkar, Amrita, Khandelwal, Sanjay, Koma, Gavin T., Kim, Hyunjun, Gruel, Yves, Rollin, Jerome, Passam, Freda, Wool, Geoffrey D., Arepally, Gowthami M., Cines, Douglas B., Rauova, Lubica, Poncz, Mortimer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388731/
https://www.ncbi.nlm.nih.gov/pubmed/37196641
http://dx.doi.org/10.1182/bloodadvances.2023009661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388731/
https://www.ncbi.nlm.nih.gov/pubmed/37196641
http://dx.doi.org/10.1182/bloodadvances.2023009661

Ejemplares similares