Microtiter plate-based chemistry and in situ screening: SuFEx-enabled lead discovery of selective AChE inhibitors

Sulphur fluoride exchange (SuFEx) is a category of click chemistry that enables covalent linking of modular units through sulphur connective hubs. Here, we reported an efficient synthesis and in situ screening method for building a library of sulphonamides on the picomolar scale by SuFEx reaction be...

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Detalles Bibliográficos
Autores principales: Tang, Kun, Li, Huan-Huan, Wu, Chengyao, Zhang, Shi-Long, Yang, Jian-Guo, Tang, Wenjian, Qin, Hua-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388794/
https://www.ncbi.nlm.nih.gov/pubmed/37501629
http://dx.doi.org/10.1080/14756366.2023.2237213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388794/
https://www.ncbi.nlm.nih.gov/pubmed/37501629
http://dx.doi.org/10.1080/14756366.2023.2237213

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