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Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa
INTRODUCTION: The primary goal of this work is to broaden and enhance the options for induction of protective CD8(+) T cells against HIV-1 and respiratory pathogens. METHODS: We explored the advantages of the parainfluenza virus 5 (PIV5) vector for delivery of pathogen-derived transgenes alone and i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390215/ https://www.ncbi.nlm.nih.gov/pubmed/37529048 http://dx.doi.org/10.3389/fimmu.2023.1186478 |
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author | Beavis, Ashley C. Wee, Edmund G. -T. Akis Yildirim, Belkis M. Borthwick, Nicola He, Biao Hanke, Tomáš |
author_facet | Beavis, Ashley C. Wee, Edmund G. -T. Akis Yildirim, Belkis M. Borthwick, Nicola He, Biao Hanke, Tomáš |
author_sort | Beavis, Ashley C. |
collection | PubMed |
description | INTRODUCTION: The primary goal of this work is to broaden and enhance the options for induction of protective CD8(+) T cells against HIV-1 and respiratory pathogens. METHODS: We explored the advantages of the parainfluenza virus 5 (PIV5) vector for delivery of pathogen-derived transgenes alone and in combination with the in-human potent regimen of simian adenovirus ChAdOx1 prime-poxvirus MVA boost delivering bi-valent mosaic of HIV-1 conserved regions designated HIVconsvX. RESULTS: We showed in BALB/c mice that the PIV5 vector expressing the HIVconsvX immunogens could be readily incorporated with the other two vaccine modalities into a single regimen and that for specific vector combinations, mucosal CD8(+) T-cell induction was enhanced synergistically by a combination of the intranasal and intramuscular routes of administration. DISCUSSION: Encouraging safety and immunogenicity data from phase 1 human trials of ChAdOx1- and MVA-vectored vaccines for HIV-1, and PIV5-vectored vaccines for SARS-CoV-2 and respiratory syncytial virus pave the way for combining these vectors for HIV-1 and other indications in humans. |
format | Online Article Text |
id | pubmed-10390215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103902152023-08-01 Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa Beavis, Ashley C. Wee, Edmund G. -T. Akis Yildirim, Belkis M. Borthwick, Nicola He, Biao Hanke, Tomáš Front Immunol Immunology INTRODUCTION: The primary goal of this work is to broaden and enhance the options for induction of protective CD8(+) T cells against HIV-1 and respiratory pathogens. METHODS: We explored the advantages of the parainfluenza virus 5 (PIV5) vector for delivery of pathogen-derived transgenes alone and in combination with the in-human potent regimen of simian adenovirus ChAdOx1 prime-poxvirus MVA boost delivering bi-valent mosaic of HIV-1 conserved regions designated HIVconsvX. RESULTS: We showed in BALB/c mice that the PIV5 vector expressing the HIVconsvX immunogens could be readily incorporated with the other two vaccine modalities into a single regimen and that for specific vector combinations, mucosal CD8(+) T-cell induction was enhanced synergistically by a combination of the intranasal and intramuscular routes of administration. DISCUSSION: Encouraging safety and immunogenicity data from phase 1 human trials of ChAdOx1- and MVA-vectored vaccines for HIV-1, and PIV5-vectored vaccines for SARS-CoV-2 and respiratory syncytial virus pave the way for combining these vectors for HIV-1 and other indications in humans. Frontiers Media S.A. 2023-07-17 /pmc/articles/PMC10390215/ /pubmed/37529048 http://dx.doi.org/10.3389/fimmu.2023.1186478 Text en Copyright © 2023 Beavis, Wee, Akis Yildirim, Borthwick, He and Hanke https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Beavis, Ashley C. Wee, Edmund G. -T. Akis Yildirim, Belkis M. Borthwick, Nicola He, Biao Hanke, Tomáš Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa |
title | Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa |
title_full | Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa |
title_fullStr | Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa |
title_full_unstemmed | Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa |
title_short | Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa |
title_sort | combined intranasal and intramuscular parainfluenza 5-, simian adenovirus chadox1- and poxvirus mva-vectored vaccines induce synergistically hiv-1-specific t cells in the mucosa |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390215/ https://www.ncbi.nlm.nih.gov/pubmed/37529048 http://dx.doi.org/10.3389/fimmu.2023.1186478 |
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