Structural insights into selective small molecule activation of PKG1α

cGMP-dependent protein kinase I-α (PKG1α) is a target for pulmonary arterial hypertension due to its role in the regulation of smooth muscle function. While most work has focused on regulation of cGMP turnover, we recently described several small molecule tool compounds which were capable of activat...

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Detalles Bibliográficos
Autores principales: Metwally, Essam, Mak, Victor, Soriano, Aileen, Zebisch, Matthias, Silvestre, H. Leonardo, McEwan, Paul A., Ermakov, Grigori, Beaumont, Maribel, Tawa, Paul, Barker, John J., Yen, Rose, Patel, Akash, Lim, Yeon-Hee, Healy, David, Hanisak, Jennifer, Cheng, Alan C., Greshock, Tom, Fischmann, Thierry O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390508/
https://www.ncbi.nlm.nih.gov/pubmed/37524852
http://dx.doi.org/10.1038/s42003-023-05095-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390508/
https://www.ncbi.nlm.nih.gov/pubmed/37524852
http://dx.doi.org/10.1038/s42003-023-05095-4

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