Cargando…

MAT as a promising therapeutic strategy against triple-negative breast cancer via inhibiting PI3K/AKT pathway

Triple-negative breast cancer (TNBC), a highly aggressive and heterogeneous subtype of breast cancer, lacks effective treatment options. Sophora flavescens Aiton, a Chinese medicinal plant, is often used in traditional Chinese medicine to treat cancer. Matrine (MAT) is an alkaloid extracted from Sop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Shijie, Zhang, Yubao, Ma, Xiaoran, Yao, Yan, Zhou, Qinqin, Zhang, Wenfeng, Zhou, Chao, Zhuang, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390516/ https://www.ncbi.nlm.nih.gov/pubmed/37524857 http://dx.doi.org/10.1038/s41598-023-39655-9

Ejemplares similares

Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K–AKT Pathway
por: Zhang, Daoyu, et al.
Publicado: (2020)

Novel therapeutic avenues in triple-negative breast cancer: PI3K/AKT inhibition, androgen receptor blockade, and beyond
por: Chan, Jack J., et al.
Publicado: (2019)

Identifying the Effect of Ursolic Acid Against Triple-Negative Breast Cancer: Coupling Network Pharmacology With Experiments Verification
por: Zhang, Yubao, et al.
Publicado: (2021)

GPRC5A Is a Negative Regulator of the Pro-Survival PI3K/Akt Signaling Pathway in Triple-Negative Breast Cancer
por: Yang, Lu, et al.
Publicado: (2021)

Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway
por: Massihnia, Daniela, et al.
Publicado: (2016)

Erianin induces triple-negative breast cancer cells apoptosis by activating PI3K/Akt pathway
por: Xu, Yonggang, et al.
Publicado: (2021)

Molecular Targets and Promising Therapeutics of Triple-Negative Breast Cancer
por: Ryu, Won-Ji, et al.
Publicado: (2021)

PRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer
por: Guo, Fengzhu, et al.
Publicado: (2023)

Ethanol Extract of Brucea javanica Seed Inhibit Triple-Negative Breast Cancer by Restraining Autophagy via PI3K/Akt/mTOR Pathway
por: Chen, Xiaohong, et al.
Publicado: (2020)

Inhibition of the PI3K/AKT pathway potentiates cytotoxicity of EGFR kinase inhibitors in triple-negative breast cancer cells
por: Yi, Yong Weon, et al.
Publicado: (2013)

Proliferation, migration and invasion of triple negative breast cancer cells are suppressed by berbamine via the PI3K/Akt/MDM2/p53 and PI3K/Akt/mTOR signaling pathways
por: Liu, Lili, et al.
Publicado: (2021)

CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway
por: Wang, Lei, et al.
Publicado: (2021)

Ceramide kinase mediates intrinsic resistance and inferior response to chemotherapy in triple‐negative breast cancer by upregulating Ras/ERK and PI3K/Akt pathways
por: Zhu, Shan, et al.
Publicado: (2021)

DEK promoted EMT and angiogenesis through regulating PI3K/AKT/mTOR pathway in triple-negative breast cancer
por: Yang, Yang, et al.
Publicado: (2017)

BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer
por: Shafei, Mai Ahmed, et al.
Publicado: (2020)

Sericin inhibits MDA-MB-468 cell proliferation via the PI3K/Akt pathway in triple-negative breast cancer
por: Niu, Lin, et al.
Publicado: (2021)

MAT2B expression correlates with poor prognosis in triple-negative breast cancer
por: Xu, Jin, et al.
Publicado: (2019)

The clinical promise of immunotherapy in triple-negative breast cancer
por: Vikas, Praveen, et al.
Publicado: (2018)

Inhibition of PI3K/Akt/mTOR overcomes cisplatin resistance in the triple negative breast cancer cell line HCC38
por: Gohr, Katharina, et al.
Publicado: (2017)

10-Gingerol Targets Lipid Rafts Associated PI3K/Akt Signaling in Radio-Resistant Triple Negative Breast Cancer Cells
por: Ediriweera, Meran Keshawa, et al.
Publicado: (2020)

PIK3CA copy-number gain and inhibitors of the PI3K/AKT/mTOR pathway in triple-negative breast cancer
por: Amato, Ottavia, et al.
Publicado: (2023)

Pseudolaric acid B induces apoptosis associated with the mitochondrial and PI3K/AKT/mTOR pathways in triple‑negative breast cancer
por: Yang, Ke, et al.
Publicado: (2023)

Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway
por: Chen, Dongshao, et al.
Publicado: (2018)

Role of PTEN, PI3K, and mTOR in Triple-Negative Breast Cancer
por: Prvanović, Mirjana, et al.
Publicado: (2021)

Actin-Like Protein 8 Promotes the Progression of Triple-Negative Breast Cancer via Activating PI3K/AKT/mTOR Pathway
por: Fan, Shaoxia, et al.
Publicado: (2021)

Nrf3 promotes the proliferation and migration of triple‑negative breast cancer by activating PI3K/AKT/mTOR and epithelial‑mesenchymal transition
por: Chen, Wan-Meng, et al.
Publicado: (2023)

Immunomodulatory Properties of PI3K/AKT/mTOR and MAPK/MEK/ERK Inhibition Augment Response to Immune Checkpoint Blockade in Melanoma and Triple-Negative Breast Cancer
por: Zhang, Zhizhu, et al.
Publicado: (2022)

Exenatide regulates Th17/Treg balance via PI3K/Akt/FoxO1 pathway in db/db mice
por: Xu, Qinqin, et al.
Publicado: (2022)

Nrf2 Negatively Regulates Melanogenesis by Modulating PI3K/Akt Signaling
por: Shin, Jung-Min, et al.
Publicado: (2014)

Preconditioning but not postconditioning treatment with resveratrol substantially ameliorates post-resuscitation myocardial dysfunction through the PI3K/Akt signaling pathway
por: Zhang, Haihong, et al.
Publicado: (2019)

Roxarsone induces angiogenesis via PI3K/Akt signaling
por: Wang, Yujing, et al.
Publicado: (2016)

PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?
por: Peng, Yan, et al.
Publicado: (2022)

Elevated estrogen receptor β expression in triple negative breast cancer cells is associated with sensitivity to doxorubicin by inhibiting the PI3K/AKT/mTOR signaling pathway
por: Lei, Shanshan, et al.
Publicado: (2020)

Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling
por: Guo, Yubo, et al.
Publicado: (2019)

Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models
por: Cocco, Stefania, et al.
Publicado: (2022)

Long noncoding RNA–mediated activation of PROTOR1/PRR5-AKT signaling shunt downstream of PI3K in triple-negative breast cancer
por: Tu, Zhenbo, et al.
Publicado: (2022)

Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway
por: Liu, Yunxia, et al.
Publicado: (2017)

MST4 negatively regulates the EMT, invasion and metastasis of HCC cells by inactivating PI3K/AKT/Snail1 axis
por: Dian, Mei-Juan, et al.
Publicado: (2021)

MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation
por: Jiang, Jianxin, et al.
Publicado: (2015)

Establishing the promising role of novel combination of triple therapeutics delivery using polymeric nanoparticles for Triple negative breast cancer therapy
por: Misra, Ranjita, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4ul328teq584vipiqa255j3tc0