Enhancers of the PAIR4 regulatory module promote distal V(H) gene recombination at the Igh locus

While extended loop extrusion across the entire Igh locus controls V(H)‐DJ(H) recombination, local regulatory sequences, such as the PAIR elements, may also activate V(H) gene recombination in pro‐B‐cells. Here, we show that PAIR‐associated V(H)8 genes contain a conserved putative regulatory element...

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Detalles Bibliográficos
Autores principales: Hill, Louisa, Jaritz, Markus, Tagoh, Hiromi, Schindler, Karina, Kostanova‐Poliakova, Daniela, Sun, Qiong, Schwickert, Tanja A, Leeb, Martin, Busslinger, Meinrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390877/
https://www.ncbi.nlm.nih.gov/pubmed/37337907
http://dx.doi.org/10.15252/embj.2022112741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10390877/
https://www.ncbi.nlm.nih.gov/pubmed/37337907
http://dx.doi.org/10.15252/embj.2022112741

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