PLX4032 resistance of patient-derived melanoma cells: crucial role of oxidative metabolism

BACKGROUND: Malignant melanoma is the most lethal form of skin cancer which shows BRAF mutation in 50% of patients. In this context, the identification of BRAF(V600E) mutation led to the development of specific inhibitors like PLX4032. Nevertheless, although its initial success, its clinical efficac...

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Detalles Bibliográficos
Autores principales: Garbarino, Ombretta, Valenti, Giulia Elda, Monteleone, Lorenzo, Pietra, Gabriella, Mingari, Maria Cristina, Benzi, Andrea, Bruzzone, Santina, Ravera, Silvia, Leardi, Riccardo, Farinini, Emanuele, Vernazza, Stefania, Grottoli, Melania, Marengo, Barbara, Domenicotti, Cinzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391174/
https://www.ncbi.nlm.nih.gov/pubmed/37534247
http://dx.doi.org/10.3389/fonc.2023.1210130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391174/
https://www.ncbi.nlm.nih.gov/pubmed/37534247
http://dx.doi.org/10.3389/fonc.2023.1210130

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