Deficiency of the Polycomb Protein RYBP and TET Methylcytosine Oxidases Promotes Extensive CpG Island Hypermethylation and Malignant Transformation

Hypermethylation of CpG islands (CGI) is a common feature of cancer cells and predominantly affects Polycomb-associated genomic regions. Elucidating the underlying mechanisms leading to DNA hypermethylation in human cancer could help identify chemoprevention strategies. Here, we evaluated the role o...

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Detalles Bibliográficos
Autores principales: Cui, Wei, Huang, Zhijun, Jin, Seung-Gi, Johnson, Jennifer, Lau, Kin H., Hostetter, Galen, Pfeifer, Gerd P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391329/
https://www.ncbi.nlm.nih.gov/pubmed/37272752
http://dx.doi.org/10.1158/0008-5472.CAN-23-0269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391329/
https://www.ncbi.nlm.nih.gov/pubmed/37272752
http://dx.doi.org/10.1158/0008-5472.CAN-23-0269

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