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Deficiency of the Polycomb Protein RYBP and TET Methylcytosine Oxidases Promotes Extensive CpG Island Hypermethylation and Malignant Transformation

Hypermethylation of CpG islands (CGI) is a common feature of cancer cells and predominantly affects Polycomb-associated genomic regions. Elucidating the underlying mechanisms leading to DNA hypermethylation in human cancer could help identify chemoprevention strategies. Here, we evaluated the role o...

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Detalles Bibliográficos
Autores principales:	Cui, Wei, Huang, Zhijun, Jin, Seung-Gi, Johnson, Jennifer, Lau, Kin H., Hostetter, Galen, Pfeifer, Gerd P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391329/ https://www.ncbi.nlm.nih.gov/pubmed/37272752 http://dx.doi.org/10.1158/0008-5472.CAN-23-0269

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