BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance

Cancer metastasis is an extremely complex process affected by many factors. An acidic microenvironment can drive cancer cell migration toward blood vessels while also hampering immune cell activity. Here, we identified a mechanism mediated by sialyltransferases that induces an acidic tumor-permissiv...

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Detalles Bibliográficos
Autores principales: Shu, Xiaodong, Li, Jianjie, Chan, Un In, Su, Sek Man, Shi, Changxiang, Zhang, Xin, An, Tingting, Xu, Jun, Mo, Lihua, Liu, Jianlin, Wang, Yuqing, Li, Xiaoling, Deng, Min, Lei, Josh Haipeng, Wang, Chunfei, Tian, Hao, Heng, Sun, Shim, Joong Sup, Zhang, Xuanjun, Dai, Yunlu, Yao, Zhicheng, Kuang, Xiaying, Lin, Ying, Deng, Chu-Xia, Xu, Xiaoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Convergence Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391349/
https://www.ncbi.nlm.nih.gov/pubmed/37227919
http://dx.doi.org/10.1158/0008-5472.CAN-22-3398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391349/
https://www.ncbi.nlm.nih.gov/pubmed/37227919
http://dx.doi.org/10.1158/0008-5472.CAN-22-3398

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