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Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression

Parkinson’s disease (PD) is a neurodegenerative disease characterized by selective loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). We recently reported that Six2 could reverse the degeneration of DA neurons in a dephosphorylation state. Here we further identified that...

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Detalles Bibliográficos
Autores principales: Zhang, Can-tang, Qin, Deng-li, Cao, Xia-yin, Kan, Jia-shuo, Huang, Xin-xing, Gao, Dian-shuai, Gao, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391717/
https://www.ncbi.nlm.nih.gov/pubmed/37534182
http://dx.doi.org/10.1016/j.isci.2023.107049