Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells

While Mek1/2 and Gsk3β inhibition (“2i”) supports the maintenance of murine embryonic stem cells (ESCs) in a homogenous naïve state, prolonged culture in 2i results in aneuploidy and DNA hypomethylation that impairs developmental potential. Additionally, 2i fails to support derivation and culture of...

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Detalles Bibliográficos
Autores principales: Zhong, Liangwen, Gordillo, Miriam, Wang, Xingyi, Qin, Yiren, Huang, Yuanyuan, Soshnev, Alexey, Kumar, Ritu, Nanjangud, Gouri, James, Daylon, David Allis, C, Evans, Todd, Carey, Bryce, Wen, Duancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392030/
https://www.ncbi.nlm.nih.gov/pubmed/37029701
http://dx.doi.org/10.1093/procel/pwad008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392030/
https://www.ncbi.nlm.nih.gov/pubmed/37029701
http://dx.doi.org/10.1093/procel/pwad008

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