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Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells
While Mek1/2 and Gsk3β inhibition (“2i”) supports the maintenance of murine embryonic stem cells (ESCs) in a homogenous naïve state, prolonged culture in 2i results in aneuploidy and DNA hypomethylation that impairs developmental potential. Additionally, 2i fails to support derivation and culture of...
Autores principales: | Zhong, Liangwen, Gordillo, Miriam, Wang, Xingyi, Qin, Yiren, Huang, Yuanyuan, Soshnev, Alexey, Kumar, Ritu, Nanjangud, Gouri, James, Daylon, David Allis, C, Evans, Todd, Carey, Bryce, Wen, Duancheng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392030/ https://www.ncbi.nlm.nih.gov/pubmed/37029701 http://dx.doi.org/10.1093/procel/pwad008 |
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