Selective proteasome degradation of C‐terminally‐truncated human WFS1 in pancreatic beta cells

Wolfram syndrome is a monogenic disease mainly caused by mutations in the WFS1 gene. Mutations in the WFS1 gene give rise to diabetes. Here, we characterized mutant WFS1 proteins by studying the stability of full‐length wild‐type (WT) WFS1, a missense mutant P724L, and two C‐terminally truncated mut...

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Detalles Bibliográficos
Autores principales: Tokuma, Hiraku, Sakano, Daisuke, Tanabe, Katsuya, Tanizawa, Yukio, Shiraki, Nobuaki, Kume, Shoen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392043/
https://www.ncbi.nlm.nih.gov/pubmed/37440664
http://dx.doi.org/10.1002/2211-5463.13674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392043/
https://www.ncbi.nlm.nih.gov/pubmed/37440664
http://dx.doi.org/10.1002/2211-5463.13674

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