A conserved tryptophan in the acylated segment of RTX toxins controls their β(2) integrin–independent cell penetration

The acylated Repeats in ToXins (RTX) leukotoxins, the adenylate cyclase toxin (CyaA) or α-hemolysin (HlyA), bind β(2) integrins of leukocytes but also penetrate cells lacking these receptors. We show that the indoles of conserved tryptophans in the acylated segments, W876 of CyaA and W579 of HlyA, a...

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Detalles Bibliográficos
Autores principales: Osickova, Adriana, Knoblochova, Sarka, Bumba, Ladislav, Man, Petr, Kalaninova, Zuzana, Lepesheva, Anna, Jurnecka, David, Cizkova, Monika, Biedermannova, Lada, Goldsmith, Jory A., Maynard, Jennifer A., McLellan, Jason S., Osicka, Radim, Sebo, Peter, Masin, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392135/
https://www.ncbi.nlm.nih.gov/pubmed/37390987
http://dx.doi.org/10.1016/j.jbc.2023.104978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392135/
https://www.ncbi.nlm.nih.gov/pubmed/37390987
http://dx.doi.org/10.1016/j.jbc.2023.104978

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