Discovery of novel arylamide derivatives containing piperazine moiety as inhibitors of tubulin polymerisation with potent liver cancer inhibitory activity

In this work, a series of novel arylamide derivatives containing piperazine moiety were designed and synthesised as tubulin polymerisation inhibitors. Among 25 target compounds, compound 16f (MY-1121) exhibited low nanomolar IC(50) values ranging from 0.089 to 0.238 μM against nine human cancer cell...

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Detalles Bibliográficos
Autores principales: Shi, Xiao-Yi, Jiao, Huang, Zhang, Jia-Kai, Tian, Xin-Yi, Guo, Dan-Feng, Gao, Jie, Jia, Mei-Qi, Song, Jian, Zhang, Sai-Yang, Fu, Xiang-Jing, Tang, Hong-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392279/
https://www.ncbi.nlm.nih.gov/pubmed/37489043
http://dx.doi.org/10.1080/14756366.2023.2237701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392279/
https://www.ncbi.nlm.nih.gov/pubmed/37489043
http://dx.doi.org/10.1080/14756366.2023.2237701

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