Cargando…

Discovery of novel arylamide derivatives containing piperazine moiety as inhibitors of tubulin polymerisation with potent liver cancer inhibitory activity

In this work, a series of novel arylamide derivatives containing piperazine moiety were designed and synthesised as tubulin polymerisation inhibitors. Among 25 target compounds, compound 16f (MY-1121) exhibited low nanomolar IC(50) values ranging from 0.089 to 0.238 μM against nine human cancer cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Xiao-Yi, Jiao, Huang, Zhang, Jia-Kai, Tian, Xin-Yi, Guo, Dan-Feng, Gao, Jie, Jia, Mei-Qi, Song, Jian, Zhang, Sai-Yang, Fu, Xiang-Jing, Tang, Hong-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392279/ https://www.ncbi.nlm.nih.gov/pubmed/37489043 http://dx.doi.org/10.1080/14756366.2023.2237701

Ejemplares similares

Synthesis, biological evaluation and molecular docking investigation of new sulphonamide derivatives bearing naphthalene moiety as potent tubulin polymerisation inhibitors
por: Wang, Guangcheng, et al.
Publicado: (2021)

Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities
por: Wang, Pengxu, et al.
Publicado: (2021)

Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect
por: Ibrahim, Tarek S., et al.
Publicado: (2021)

Synthesis and Antifungal Activity of Novel Triazole Compounds Containing Piperazine Moiety
por: Wang, Yanwei, et al.
Publicado: (2014)

Anticancer sulfonamide hybrids that inhibit bladder cancer cells growth and migration as tubulin polymerisation inhibitors
por: Liu, Jia, et al.
Publicado: (2019)

A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors
por: Liu, Wenjing, et al.
Publicado: (2021)

Design, synthesis, and biological evaluation of new arylamide derivatives possessing sulfonate or sulfamate moieties as steroid sulfatase enzyme inhibitors
por: El-Gamal, Mohammed I., et al.
Publicado: (2016)

Antiproliferative benzothiazoles incorporating a trimethoxyphenyl scaffold as novel colchicine site tubulin polymerisation inhibitors
por: Fu, Dong-Jun, et al.
Publicado: (2020)

Design, synthesis and biological evaluation of novel diarylpyridine derivatives as tubulin polymerisation inhibitors
por: Yang, Shanbo, et al.
Publicado: (2022)

Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors
por: Sardaru, Monica-Cornelia, et al.
Publicado: (2020)

Synthesis and antitumor activity of litseaone B analogues as tubulin polymerisation inhibitors
por: Yang, Wei, et al.
Publicado: (2022)

A One-Pot Biginelli Synthesis and Characterization of Novel Dihydropyrimidinone Derivatives Containing Piperazine/Morpholine Moiety
por: Bhat, Mashooq Ahmad, et al.
Publicado: (2018)

Synthesis and Antimicrobial Activity of New Mannich Bases with Piperazine Moiety
por: Janowska, Sara, et al.
Publicado: (2023)

Benzimidazoles Containing Piperazine Skeleton at C-2 Position as Promising Tubulin Modulators with Anthelmintic and Antineoplastic Activity
por: Anichina, Kameliya, et al.
Publicado: (2023)

Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors
por: Çeçen, Muhammed, et al.
Publicado: (2020)

Deletion of Rv2571c Confers Resistance to Arylamide Compounds in Mycobacterium tuberculosis
por: Shelton, Catherine D., et al.
Publicado: (2021)

The discovery of tubulin
por: Wells, William A.
Publicado: (2005)

Discovery of Novel Tetrazoles Featuring a Pyrazole Moiety as Potent and Highly Selective Antifungal Agents
por: Chi, Xiaochen, et al.
Publicado: (2023)

Synthesis of Some Benzofuran Derivatives Containing Pyrimidine Moiety as Potent Antimicrobial Agents
por: Venkatesh, Talavara, et al.
Publicado: (2018)

Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors
por: Wang, Guangcheng, et al.
Publicado: (2021)

Sodium thiosulfate acts as a hydrogen sulfide mimetic to prevent intimal hyperplasia via inhibition of tubulin polymerisation
por: Macabrey, Diane, et al.
Publicado: (2022)

Novel N-arylamide derivatives of (S)-perillic acid ((S)-PA): in vitro and in vivo cytotoxicity and antitumor evaluation
por: Mukhtar, Yusif Mohammed, et al.
Publicado: (2019)

Discovery of novel quinazoline derivatives bearing semicarbazone moiety as potent EGFR kinase inhibitors
por: Tu, Yuanbiao, et al.
Publicado: (2018)

Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors
por: Jiang, Xiangyi, et al.
Publicado: (2023)

Design, Synthesis and Cytotoxic Evaluation of Novel Chalcone Derivatives Bearing Triazolo[4,3-a]-quinoxaline Moieties as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects
por: Alswah, Mohamed, et al.
Publicado: (2017)

Synthesis, Characterization, and Anti-Inflammatory Activities of Methyl Salicylate Derivatives Bearing Piperazine Moiety
por: Li, Jingfen, et al.
Publicado: (2016)

Synthesis of enantiomerically pure N-(2,3-dihydroxypropyl)arylamides via oxidative esterification
por: Raghunadh, Akula, et al.
Publicado: (2013)

Synthesis and biological investigations of 3β-aminotropane arylamide derivatives with atypical antipsychotic profile
por: Stefanowicz, Jacek, et al.
Publicado: (2018)

Atom-Economical Synthesis of N-Arylamides Utilizing Isopropenyl Esters with Heterogeneous Acid Catalysts
por: Ichitsuka, Tomohiro, et al.
Publicado: (2023)

Discovery of Novel Diarylamide N-Containing Heterocyclic Derivatives as New Tubulin Polymerization Inhibitors with Anti-Cancer Activity
por: Liu, Xu, et al.
Publicado: (2021)

Discovery of potent tubulin inhibitors targeting the colchicine binding site via structure-based lead optimization and antitumor evaluation
por: Liu, Wei, et al.
Publicado: (2023)

The antidepressant- and anxiolytic-like activities of new xanthone derivative with piperazine moiety in behavioral tests in mice
por: Pytka, Karolina, et al.
Publicado: (2016)

Synthesis of N-Mannich bases of berberine linking piperazine moieties revealing anticancer and antioxidant effects
por: Mistry, Bhupendra, et al.
Publicado: (2017)

Design, Synthesis, and Biological Evaluation of Novel Benzofuran Derivatives Bearing N-Aryl Piperazine Moiety
por: Ma, Yulu, et al.
Publicado: (2016)

Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors
por: Ullah, Saif, et al.
Publicado: (2022)

Tertiary sulphonamide derivatives as dual acting small molecules that inhibit LSD1 and suppress tubulin polymerisation against liver cancer
por: Ding, Lijuan, et al.
Publicado: (2021)

Design, synthesis and evaluation of dihydro-1H-indene derivatives as novel tubulin polymerisation inhibitors with anti-angiogenic and antitumor potency
por: Xu, Shengtao, et al.
Publicado: (2023)

Halogen Bond Motifs in Cocrystals of N,N,O and N,O,O Acceptors Derived from Diketones and Containing a Morpholine or Piperazine Moiety
por: Sušanj, Ruđer, et al.
Publicado: (2022)

Synthesis and antioxidant activity of some 1-aryl/aralkyl piperazine derivatives with xanthine moiety at N4
por: Andonova, Lily, et al.
Publicado: (2014)

Piperazine-2,3,5,6-tetraone
por: Jia, Jing-Jing, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_4tpm3qhjtekvcm1luea8klmovt